Ontario County deputies say the crash happened around 10 o'clock on State Route 14 in the Town of Phelps. Deputies say a 2012 Subaru sedan was traveling south when it failed to stay in its lane.
The car crossed into the opposite lane of traffic and sideswiped a tractor trailer that was hauling diesel fuel. The car then hit another car head on.
Deputies say the driver of the car, Joseph Spezio, 64, of Naples, Florida and Jeffrey LaDue, 46, of Rochester both suffered critical injuries.
They were taken to Strong Hospital by way of Mercy Flight.