Police were called to the 400 block of Bernard Street just before 3:30 a.m. Saturday morning.
Rochester Police say they found a man in his early twenties with a gun shot wound. He was transported to Strong Memorial Hospital where he was pronounced dead.
A second person was also shot in the incident. He was transported to Rochester General Hospital but a private vehicle with non life-threatening injuries.
Rochester Police are unsure of the relationship between the two victims.