Nolan caught a short TD pass from Cody Argus to break open a scoreless game midway through the fourth quarter. After a Wayne fumble, Nolan scored again from two yards out.
Connor Hollenbeck hit Cory McNamara for Wayne's only points with 90 seconds left, but Pal-Mac recovered the onside kick to preserve the win.
It was the first loss of the year for Wayne (4-1). Pal-Mac is 3-2.