A car and a van hit head on, then the car was hit by another car. The driver of the van had minor injuries. The two people in the second car were not injured.
The two people in the first car were flown by Mercy Flight to Erie County Medical Center.
The passenger, 19-year-old Kelsey Milks, was pronounced dead just after 8:00 p.m.
The cause of the crash remains under investigation.