Monroe County Sheriff's Deputies were called to the scene around 7:30 p.m. at Route 64 and Boughton Hill Road.
They say the driver of a car failed to stop at a stop sign on Boughton Hill Road, slamming into an pickup truck travelling on Route 64.
Three people were in the car: one of them was killed and two others were seriously injured. The driver of the truck was also seriously injured. The three injured people were taken to Strong Hospital.