The Braves held a 6-4 lead at halftime and saw their lead cut to one soon after play resumed before a 5-1 scoring burst.
Midfielder Lauren D'Amore, who had four goals, while Jordan Johnson added two goals and two assists for Canandaigua. Macy Marafioti and Kendall D'Amore each tallied a goal and two assists.
For the Eagles, Lauren Gerrie and Jourdan Roemer led the charge with three goals each. Lisa Rogers also chipped in two goals.
The Braves (16-3) next play Hamburg of Section VI in the state quarterfinals on Saturday at 8 p.m. at Buffalo's All-High Stadium.